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KMID : 0043320110340122015
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Archives of Pharmacal Research
2011 Volume.34 No. 12 p.2015 ~ p.2020
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New glycosides from Dracocephalum tanguticum maxim
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Zeng Qi
Chang Ruijie
Qin Jiangjiang
Cheng Xiangrong
Zhang Weidong
Jin Huizi
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Abstract
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Four new glycosides, luteolin-7-methoxy-3′-O-(3″-O-acetyl)-β-D-gluco pyranuronic acid-6″-methyl ester (1), benzyl-6-[(2E)-2-butenoate]-β-D-glucopyranoside (2), 2-methoxy-4-(2-propen-1-yl)penyl-6-acetate-β-D-glucopyranoside (3), and 2-methoxy-4-(2-propen-1-yl)penyl-6-[(2E)-2-butenoate]-β-D-glucopyranoside (4), along with benzyl-β-D-glucopyranoside (5), 2-methoxy-4-(2-propen-1-yl)penyl-β-D-glucopyranoside (6), and pectolarigenin (7), were isolated from the whole plant of Dracocephalum tanguticum Maxim. The structures of 1-4 were elucidated by detailed spectroscopic analyses, including HR-ESI-MS and 2D NMR spectroscopic data. The inhibitory effects against nitric oxide production in LPS-stimulated RAW264.7 cells of all seven compounds were also evaluated.
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KEYWORD
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Dracocephalum tanguticum Maxim, Glycosides, Nitric oxide production
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